What is Letrozole (Femara)?
Like most of the AIs we look at for using alongside anabolic steroids, Letrozole was also developed for the medical treatment of breast cancer in post menopausal women.
![Letrozole Structure](https://steroidcycle.org/wp-content/uploads/letrozole-structure.png)
The reason it is only used in women of such an age is due to its powerful estrogen blocking ability which would have serious health implications for pre-menopausal women, but for male steroid users in particular it is this trait that makes AIs like Letrozole so appealing as we aim to combat the adverse effects of estrogen when using aromatizing steroids.
Letrozole is able to lower your overall estrogen levels because it blocks the aromatase enzyme. This is in contrast to the other popular category of estrogen control drugs for steroids users, SERMs, which only target very specific areas of the body. This allows Letrozole to combat a wider range of estrogenic side effects caused by steroids, with the two main ones being gynecomastia and water retention. This will also help prevent the high blood pressure that can come along when excess water retention is not addressed.
Letrozole Effects for Gynecomastia and Estrogen Control
Letrozole is such a powerful AI and so effective at controlling estrogen that some steroid users have reported being able to successfully reverse the effects of gyno when using this drug. Even so, it is always preferable to try and prevent gyno from rearing its head at all rather than depending on any drug to reverse it; because while some people might have luck with this when using Letrozole, others will find that more advanced gyno is still not reversible without surgery.
Letrozole will reduce the entire circulating levels of estrogen in the body, unlike SERM drugs which will target specific receptors and are most useful for controlling gyno – while Letrozole will also be powerful for controlling water retention which is the other main adverse effect of steroid use that we all want to avoid.
When using Letrozole you can expect your estrogen levels to be reduced considerably as this is the most powerful AI we can access currently. In fact it could result in your estrogen dropping too low at times (yes, this can be an issue for men as we do require some small amount of estrogen for normal functioning). But during steroid cycle your main aim with an AI is to reduce, minimize and ultimately prevent the estrogenic side effects that are almost certain to come about when using steroids that aromatize.
There are additional benefits to this estrogen controlling power of Letrozole too: because it means you can prevent water retention, your physique will take on a much harder, drier and ripped appearance because you’re not holding on to water. This can make Letrozole particularly useful for competitive bodybuilders who want to eliminate as much fluid retention as possible and Letrozole is the best AI to help with this goal.
Letrozole Dosage
Even at very low doses Letrozole is a potent drug so you do not require a lot of it to benefit from its full effects. Unlike with many of the other AIs or SERMs you might use as a steroid user where doses are normally higher than those used for medical treatment, with Letrozole we can get away with using a similar dose or even lower than is administered when the drug is used medically.
Letrozole Dosage During Anabolic Steroid Use
Making the mistake of taking too much Letrozole during steroid use will have no benefit and bring about negative effects, like fatigue. So it’s critical to maintain a sensible dose.
With a medical dose usually around 2.5mg daily, we would look at no higher than that and most of the time even lower. To protect from estrogen related side effects during steroid use a dose of as low as 0.5mg to 1.25mg every two days is often enough for excellent estrogenic related protection for most men.
Only if you are experiencing early signs of gynecomastia would increasing the dose at this time up to 2.5mg per day can potentially even fully reverse the symptoms; but be prepared for a noticeable zap in energy during this time. Once gyno symptoms subside it’s important to reduce your Letrozole dose back down to regular estrogenic protection levels.
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